Crystallographic analysis of a thermoactive nitrilase.

  title={Crystallographic analysis of a thermoactive nitrilase.},
  author={Joanna E Raczynska and Constantinos E. Vorgias and Garabed Antranikian and Wojciech Rypniewski},
  journal={Journal of structural biology},
  volume={173 2},
The nitrilase superfamily is a large and diverse superfamily of enzymes that catalyse the cleavage of various types of carbon-nitrogen bonds using a Cys-Glu-Lys catalytic triad. Thermoactive nitrilase from Pyrococcus abyssi (PaNit) hydrolyses small aliphatic nitriles like fumaro- and malononitryl. Yet, the biological role of this enzyme is unknown. We have… CONTINUE READING