Crystallization from Volatile Deep Eutectic Solvents

@article{Potticary2020CrystallizationFV,
  title={Crystallization from Volatile Deep Eutectic Solvents},
  author={Jason Potticary and Charlie L Hall and Victoria Hamilton and James F. McCabe and Simon R Hall},
  journal={arXiv: Chemical Physics},
  year={2020}
}
A new class of deep eutectic solvents are presented where one component of the system is inherently volatile, enabling a premeditated, auto-destructive capability which leads inexorably to a series of novel crystal structures. These volatile deep eutectic solvents are easily-formed liquids with a greatly depressed melting point and exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that the hydrogen-bond donor component is volatile when exposed… Expand
7 Citations

Figures and Tables from this paper

A new olanzapine cocrystal obtained from volatile deep eutectic solvents and determined by 3D electron diffraction.
TLDR
Olanzapine and phenol cocrystallize in the triclinic space group P1, supporting the hypothesis of a dimeric growth unit, where a centrosymmetric dimer is stabilized by multiple weak C-H...π interactions and forms double N-H)...N hydrogen bonding with adjacent dimers. Expand
Metastable crystalline phase formation in deep eutectic systems revealed by simultaneous synchrotron XRD and DSC.
TLDR
Deep eutectic systems containing the pharmaceuticals metacetamol, 2-ethoxybenzamide or benzamide as binary mixtures with phenol revealed new crystalline phases melting either before or with crystals of phenol, highlighting their lower stabilities. Expand
Racemic Conglomerate Formation via Crystallization of Metaxalone from Volatile Deep Eutectic Solvents
The pharmaceutical metaxalone (MTX) was obtained as a conglomerate Form A-R/S, via a newly reported crystallization method exploiting volatile deep eutectic solvents. Homochiral crystals of Form A-...
Fracto-eutectogels: SDS fractal dendrites via counterion condensation in a deep eutectic solvent.
TLDR
The observation of self-assembled SDS fractal dendrites with dimensions up to ∼mm in glyceline at SDS concentrations as low as cSDS ∼ 0.1 wt%. Expand

References

SHOWING 1-10 OF 29 REFERENCES
Deep eutectic solvents: syntheses, properties and applications.
TLDR
All works discussed in this review aim at demonstrating that Deep Eutectic Solvents not only allow the design of eco-efficient processes but also open a straightforward access to new chemicals and materials. Expand
Liquid pharmaceuticals formulation by eutectic formation
Abstract The amphiphilic nature of many pharmaceutical active ingredients often makes them difficult to solubilise and leads to significant wastage through non-optimal dosage. In this study it isExpand
A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: Solubility and permeability studies
TLDR
The efficiency of THEDES as a new formulation for the enhancement of the bioavailability of APIs by changing the physical state of the molecules from a solid dosage to a liquid system is demonstrated. Expand
Mechanochemically Induced Conversion of Crystalline Benzamide Polymorphs by Seeding.
TLDR
A complete transformation of form I into the metastable form III by mechanochemical treatment has been achieved and nicotinamide molecules were incorporated statistically in the crystal lattice of benzamide form III during the conversion. Expand
Mesoscopic Solute-Rich Clusters in Olanzapine Solutions
An organic molecule may crystallize in numerous distinct lattices, and the slow and unpredictable transitions between multiple crystal forms are a significant concern in its pharmaceuticalExpand
Design of controlled release systems for THEDES-Therapeutic deep eutectic solvents, using supercritical fluid technology.
TLDR
A therapeutic DES based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC), providing important clues for the development of carriers for the sustainable delivery of bioactive compounds. Expand
Physicochemical characterization of the orthorhombic polymorph of paracetamol crystallized from solution.
TLDR
This paper describes a method for the laboratory-scale crystallization of the orthorhombic polymorph (form II) of paracetamol (acetaminophen) from solution and compares the solid-state properties of form II with those of form I, with particular emphasis on the crystallography, crystal morphology, thermal behavior, and compaction properties. Expand
Mechanically Induced Amorphization of Drugs: A Study of the Thermal Behavior of Cryomilled Compounds
TLDR
It was seen that compounds which have high surface crystallization tendency will exhibit the double exotherm during heating, and surface crystal growth rates around Tg were found to be highest for compounds showing the doubleExotherm in the DSC. Expand
Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III.
TLDR
Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax, and one structure suggested has a bilayer motif, held together by O-H...O(H) hydrogen bonds, and helps explain the difficulty associated with preparing this form from solution. Expand
Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior.
TLDR
Ultrasound-assisted crystallization (sonocrystallization) was used to prepare a mixture of nano- and micrometer-sized crystals of the monoclinic form of paracetamol, leading to enhanced tabletability without the use of excipients, particle coating, salt, or cocrystal formation. Expand
...
1
2
3
...