Crystallization chaperone strategies for membrane proteins.

Abstract

From G protein-coupled receptors to ion channels, membrane proteins represent over half of known drug targets. Yet, structure-based drug discovery is hampered by the dearth of available three-dimensional models for this large category of proteins. Other than efforts to improve membrane protein expression and stability, current strategies to improve the… (More)
DOI: 10.1016/j.ymeth.2011.08.004

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