Crystallization and structure determination of bovine profilin at 2.0 A resolution.

  title={Crystallization and structure determination of bovine profilin at 2.0 A resolution.},
  author={Eila S. Cedergren-Zeppezauer and Nalin C. W. Goonesekere and Michael D. Rozycki and James C. Myslik and Zbigniew Dauter and Uno Lindberg and Clarence Schutt},
  journal={Journal of molecular biology},
  volume={240 5},
Profilin regulates the behavior of the eukaryotic microfilament system through its interaction with non-filamentous actin. It also binds several ligands, including poly(L-proline) and the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Bovine profilin crystals (space group C2; a = 69.15 A, b = 34.59 A, c = 52.49 A; alpha = gamma = 90 degrees, beta = 92.56 degrees) were grown from a mixture of poly(ethylene glycol) 400 and ammonium sulfate. X-ray diffraction data… CONTINUE READING


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