Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea.

@article{Mechaly2009CrystallizationAP,
  title={Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea.},
  author={Ariel E. Mechaly and Augusto Bellomio and Koldo Morante and Juan Manuel Gonz{\'a}lez-Ma{\~n}as and Diego M. A. Gu{\'e}rin},
  journal={Acta crystallographica. Section F, Structural biology and crystallization communications},
  year={2009},
  volume={65 Pt 4},
  pages={357-60}
}
Sea anemones produce water-soluble toxins that have the ability to interact with cell membranes and form pores within them. The mechanism of pore formation is based on an initial binding step followed by oligomerization and membrane insertion. Although the final structure of the pore remains unclear, biochemical studies indicate that it consists of a tetramer with a functional radius of approximately 1.1 nm. Since four monomers seem to be insufficient to build a pore of this size, the currently… CONTINUE READING

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