Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor.

@article{Wickham2007CrystallizationAP,
  title={Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor.},
  author={Joseph Wickham and Scott Thomas Russell Walsh},
  journal={Acta crystallographica. Section F, Structural biology and crystallization communications},
  year={2007},
  volume={63 Pt 10},
  pages={
          865-9
        }
}
The interleukin-7 (IL-7) signaling pathway plays an essential role in the development, proliferation and homeostasis of T and B cells in cell-mediated immunity. Understimulation and overstimulation of the IL-7 signaling pathway leads to severe combined immunodeficiency, autoimmune reactions, heart disease and cancers. Stimulation of the IL-7 pathway begins with IL-7 binding to its alpha-receptor, IL-7R alpha. Protein crystals of unglycosylated and glycosylated complexes of human IL-7-IL-7R… CONTINUE READING

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