Crystallization and preliminary X-ray diffraction analysis of human adenovirus.

@article{Reddy2010CrystallizationAP,
  title={Crystallization and preliminary X-ray diffraction analysis of human adenovirus.},
  author={V. Sivaprasad Reddy and S. Kundhavai Natchiar and Lance D Gritton and T-M Mullen and Phoebe L. Stewart and Glen R. Nemerow},
  journal={Virology},
  year={2010},
  volume={402 1},
  pages={209-14}
}
Replication-defective and conditionally replicating adenovirus (AdV) vectors are currently being utilized in approximately 25% of human gene transfer clinical trials. Unfortunately, progress in vector development has been hindered by a lack of accurate structural information. Here we describe the crystallization and preliminary X-ray diffraction analysis of a HAdV5 vector that displays a short flexible fiber derived from HAdV35. Crystals of Ad35F were grown in 100mM HEPES pH 7.0, 200mM Ca(OAc… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…