Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.

@article{Nunes2004CrystallizationAP,
  title={Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.},
  author={F{\'a}bio M Nunes and Ricardo Apar{\'i}cio and Maria Auxiliadora Morim Santos and Rodrigo Villares Portugal and Sandra Martha Gomes Dias and Francisco de Assis Rocha Neves and Luiz Alberto Simeoni and J. D. Baxter and Paul D. Webb and Igor Polikarpov},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2004},
  volume={60 Pt 10},
  pages={1867-70}
}
Thyroid hormone receptors (TR) play critical roles in virtually all tissues. The TR ligand-binding domain (LBD) participates in important activities, such as transcriptional activation and repression, through conformational changes induced by hormone binding. Two crystal forms of isoform alpha1 of the human thyroid hormone receptor LBD (hTRalpha1) in complex with the thyroid hormones T3 and Triac were obtained. The hTRalpha1-T3 complex was crystallized in a previously unobserved crystal form… CONTINUE READING