Crystallization and preliminary X-ray analysis of human alpha-galactosidase A complex.


Human alpha-galactosidase A (alpha-D-galactoside galactohydrolase; EC, the glycosylated lysosomal enzyme deficient in Fabry disease, has been crystallized as a complex with the inhibitor N-6-aminohexanoyl-alpha-D-galactopyranosylamine. The "hanging drop" method of vapor diffusion was used to grow crystals from solutions containing 50 mM sodium… (More)


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