Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.

@article{OReilly2005CrystallineAA,
  title={Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.},
  author={Katherine M.A. O'Reilly and Richard P Phipps and Thomas H Thatcher and Beth A Graf and John Van Kirk and Patricia J. Sime},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={288 6},
  pages={L1010-6}
}
Inhalation of crystalline (CS) and amorphous silica (AS) results in human pulmonary inflammation. However, silicosis develops only following CS exposure, and the pathogenic mechanisms are poorly understood. This report describes the differential abilities of CS and AS to directly upregulate the early inflammatory mediator COX-2, the recently identified prostaglandin E (PGE) synthase and the downstream mediator PGE2 in primary human lung fibroblasts. Increased cyclooxygenase (COX)-2 gene… CONTINUE READING

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