Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

Abstract

Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B. The crystal structures of both wild-type and mutated (Gly6->Arg) horse cyclophilin B are presented. The mutation… (More)
DOI: 10.1186/1756-0500-5-626

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