Crystal structures of two mutants that have implications for the folding of bovine pancreatic ribonuclease A.

@article{Pearson1998CrystalSO,
  title={Crystal structures of two mutants that have implications for the folding of bovine pancreatic ribonuclease A.},
  author={Matthew A. Pearson and P. Andrew Karplus and R W Dodge and John H. Laity and Harold A. Scheraga},
  journal={Protein science : a publication of the Protein Society},
  year={1998},
  volume={7 5},
  pages={
          1255-8
        }
}
The Tyr92-Pro93 peptide group of bovine pancreatic ribonuclease A (RNase A) exists in the cis conformation in the native state. From unfolding/refolding kinetic studies of the disulfide-intact wild-type protein and of a variant in which Pro93 had been replaced by Ala, it had been suggested that the Tyr92-Ala93 peptide group also exists in the cis conformation in the native state. Here, we report the crystal structure of the P93A variant. Although there is disorder in the region of residues 92… CONTINUE READING

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