Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog.

@article{Suto2006CrystalSO,
  title={Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog.},
  author={Kyoko Suto and Yoshihiro Shimizu and Kazunori Watanabe and Takuya Ueda and Shuya Fukai and Osamu Nureki and Kozo Tomita},
  journal={The EMBO journal},
  year={2006},
  volume={25 24},
  pages={
          5942-50
        }
}
Eubacterial leucyl/phenylalanyl-tRNA protein transferase (L/F-transferase), encoded by the aat gene, conjugates leucine or phenylalanine to the N-terminal Arg or Lys residue of proteins, using Leu-tRNA(Leu) or Phe-tRNA(Phe) as a substrate. The resulting N-terminal Leu or Phe acts as a degradation signal for the ClpS-ClpAP-mediated N-end rule protein degradation pathway. Here, we present the crystal structures of Escherichia coli L/F-transferase and its complex with an aminoacyl-tRNA analog… CONTINUE READING

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