Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities.

@article{Steiner2002CrystalSO,
  title={Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities.},
  author={Thomas M. Steiner and Jens T. Kaiser and Snezan Marinkoviç and Robert Huber and Markus C Wahl},
  journal={The EMBO journal},
  year={2002},
  volume={21 17},
  pages={4641-53}
}
Microbial transcription modulator NusG interacts with RNA polymerase and termination factor rho, displaying striking functional homology to eukaryotic Spt5. The protein is also a translational regulator. We have determined crystal structures of Aquifex aeolicus NusG showing a modular design: an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold. The structures reveal bona fide nucleic acid binding sites, and nucleic acid… CONTINUE READING