Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs.

@article{Su2000CrystalSO,
  title={Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs.},
  author={Shengchang Su and Yi Gui Gao and Howard Robinson and Y-C. Liaw and S. P. Edmondson and John Shriver and Andrew H-J Wang},
  journal={Journal of molecular biology},
  year={2000},
  volume={303 3},
  pages={395-403}
}
Sso7d and Sac7d are two small chromatin proteins from the hyperthermophilic archaeabacterium Sulfolobus solfataricus and Sulfolobus acidocaldarius, respectively. The crystal structures of Sso7d-GTGATCGC, Sac7d-GTGATCGC and Sac7d-GTGATCAC have been determined and refined at 1.45 A, 2.2 A and 2.2 A, respectively, to investigate the DNA binding property of Sso7d/Sac7d in the presence of a T-G mismatch base-pair. Detailed structural analysis revealed that the intercalation site includes the T-G… CONTINUE READING