Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

  title={Crystal structures of the M1 and M4 muscarinic acetylcholine receptors},
  author={David M Thal and Bingfa Sun and Dan Feng and Vindhya Nawaratne and Katie Leach and Christian C. Felder and Mark G. Bures and David A. Evans and William I Weis and Priti Bachhawat and Tong Sun Kobilka and Patrick M. Sexton and Brian K. Kobilka and Arthur Christopoulos},
Muscarinic M1–M5 acetylcholine receptors are G-protein-coupled receptors that regulate many vital functions of the central and peripheral nervous systems. In particular, the M1 and M4 receptor subtypes have emerged as attractive drug targets for treatments of neurological disorders, such as Alzheimer’s disease and schizophrenia, but the high conservation of the acetylcholine-binding pocket has spurred current research into targeting allosteric sites on these receptors. Here we report the… CONTINUE READING
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