Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

@article{Zhou2014CrystalSO,
  title={Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA},
  author={Lijun Zhou and Jing Hang and Yulin Zhou and Ruixue Wan and Guifeng Lu and Ping Yin and Chuangye Yan and Yigong Shi},
  journal={Nature},
  year={2014},
  volume={506},
  pages={116-120}
}
Splicing of precursor messenger RNA (pre-mRNA) in eukaryotic cells is carried out by the spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs) and a number of accessory factors and enzymes. Each snRNP contains a ring-shaped subcomplex of seven proteins and a specific RNA molecule. The U6 snRNP contains a unique heptameric Lsm protein complex, which specifically recognizes the U6 small nuclear RNA at its 3′ end. Here we report the crystal structures of the heptameric Lsm… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS