Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

@article{Collins2008CrystalSO,
  title={Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants},
  author={Patrick J. Collins and Lesley F. Haire and Yi Pu Lin and Junfeng Liu and Rupert J. M. Russell and Philip A. Walker and John J. Skehel and Stephen R. Martin and Alan J. Hay and Steven J. Gamblin},
  journal={Nature},
  year={2008},
  volume={453},
  pages={1258-1261}
}
The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public health priority. Antiviral drugs are seen as essential requirements for control of initial influenza outbreaks caused by a new virus, and in pre-pandemic plans there is a heavy reliance on drug stockpiles. The principal target for these drugs is a virus surface glycoprotein, neuraminidase, which facilitates the release of nascent virus and thus the spread of… CONTINUE READING
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