Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

  title={Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants},
  author={P. Collins and L. Haire and Y. P. Lin and J. Liu and R. Russell and P. A. Walker and J. Skehel and S. Martin and A. Hay and S. Gamblin},
  • P. Collins, L. Haire, +7 authors S. Gamblin
  • Published 2008
  • Biology, Medicine
  • Nature
  • The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public health priority. Antiviral drugs are seen as essential requirements for control of initial influenza outbreaks caused by a new virus, and in pre-pandemic plans there is a heavy reliance on drug stockpiles. The principal target for these drugs is a virus surface glycoprotein, neuraminidase, which facilitates the release of nascent virus and thus the spread of… CONTINUE READING
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