Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.

  title={Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.},
  author={Ganesh Jawahar Swaminathan and Daniel E. Holloway and Richard A. Colvin and Gabriele K Campanella and Anastassios C Papageorgiou and Andrew D Luster and Keshab R. Acharya},
  volume={11 5},
We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet… CONTINUE READING

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