Crystal structures of nucleosome core particles containing the '601' strong positioning sequence.

@article{Vasudevan2010CrystalSO,
  title={Crystal structures of nucleosome core particles containing the '601' strong positioning sequence.},
  author={Dileep Vasudevan and Eugene Chua and Curt A Davey},
  journal={Journal of molecular biology},
  year={2010},
  volume={403 1},
  pages={1-10}
}
Nucleosome positioning plays a key role in genomic regulation by defining histone-DNA context and by modulating access to specific sites. Moreover, the histone-DNA register influences the double-helix structure, which in turn can affect the association of small molecules and protein factors. Analysis of genomic and synthetic DNA has revealed sequence motifs that direct nucleosome positioning in vitro; thus, establishing the basis for the DNA sequence dependence of positioning would shed light… CONTINUE READING
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