Crystal structures of interleukin 17A and its complex with IL-17 receptor A.

@article{Liu2013CrystalSO,
  title={Crystal structures of interleukin 17A and its complex with IL-17 receptor A.},
  author={Shenping Liu and Xi Song and Boris A. Chrunyk and Suman Shanker and Lise R. Hoth and Eric S. Marr and Matthew C. Griffor},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={1888}
}
The constituent polypeptides of the interleukin-17 family form six different homodimeric cytokines (IL-17A-F) and the heterodimeric IL-17A/F. Their interactions with IL-17 receptors A-E (IL-17RA-E) mediate host defenses while also contributing to inflammatory and autoimmune responses. IL-17A and IL-17F both preferentially engage a receptor complex containing one molecule of IL-17RA and one molecule of IL-17RC. More generally, IL-17RA appears to be a shared receptor that pairs with other members… CONTINUE READING