Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.

@article{Malay2008CrystalSO,
  title={Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.},
  author={Ali D. Malay and Takashi Umehara and Kazuko Matsubara-Malay and Balasundaram Padmanabhan and Shigeyuki Yokoyama},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 20},
  pages={
          14022-31
        }
}
The assembly of core histones onto eukaryotic DNA is modulated by several histone chaperone complexes, including Asf1, CAF-1, and HIRA. Asf1 is a unique histone chaperone that participates in both the replication-dependent and replication-independent pathways. Here we report the crystal structures of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2… CONTINUE READING

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Crystal Structures of Asf1 with Hip1 or Cac2

F. Mousson, A. Lautrette, +8 authors F. Ochsenbein
  • MAY 16,
  • 2005
VIEW 1 EXCERPT