Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics.

@article{Stollar2003CrystalSO,
  title={Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics.},
  author={Elliott J Stollar and Ugo Mayor and Simon C. Lovell and Luca Federici and Stefan Freund and A. R. Fersht and Ben F Luisi},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={43699-708}
}
We report the crystal structures and biophysical characterization of two stabilized mutants of the Drosophila Engrailed homeodomain that have been engineered to minimize electrostatic repulsion. Four independent copies of each mutant occupy the crystal lattice, and comparison of these structures illustrates variation that can be partly ascribed to networks of correlated conformational adjustments. Central to one network is leucine 26 (Leu26), which occupies alternatively two side chain… CONTINUE READING

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