Crystal structures of biapenem and tebipenem complexed with penicillin-binding proteins 2X and 1A from Streptococcus pneumoniae.

@article{Yamada2008CrystalSO,
  title={Crystal structures of biapenem and tebipenem complexed with penicillin-binding proteins 2X and 1A from Streptococcus pneumoniae.},
  author={Mototsugu Yamada and Takashi Watanabe and Nobuyoshi Baba and Yasuo Takeuchi and Fukuichi Ohsawa and Shuichi Gomi},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 6},
  pages={2053-60}
}
Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Tebipenem is the active form of tebipenem pivoxil, a novel oral carbapenem antibiotic that has a high level of bioavailability in humans, in addition to the above-mentioned features. beta-lactam antibiotics, including carbapenems, target penicillin-binding proteins (PBPs), which are membrane-associated… CONTINUE READING

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