Crystal structures of azathioprine dihydrate and 6-methylmercaptopurine trihydrate.

@article{Cook1975CrystalSO,
  title={Crystal structures of azathioprine dihydrate and 6-methylmercaptopurine trihydrate.},
  author={William J. Cook and Charles E. Bugg},
  journal={Journal of pharmaceutical sciences},
  year={1975},
  volume={64 2},
  pages={221-25}
}
The crystal and molecular structures of 6-methylmercaptopurine trihydrate and of azathioprine dihydrate were determined by the use of three-dimensional, X-ray, diffractometer data and were refined by least squares. Both molecules crystallize in the N(9)-H tautomer form, in contrast to the N(7)-H tautomer form found in crystals of 6-mercaptopurine. Unlike 6-mercaptopurine, or other thiopurines that have unsubstituted thio groups, the sulfur atoms of 6-methylmercaptopurine and azathioprine do not… CONTINUE READING