Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.

@article{Schumacher2004CrystalSO,
  title={Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.},
  author={Maria A. Schumacher and Matthew E Crum and Marshall C Miller},
  journal={Structure},
  year={2004},
  volume={12 5},
  pages={849-60}
}
Small conductance Ca2+-activated K+ channels (SK channels) are composed of the pore-forming alpha subunit and calmodulin (CaM). CaM binds to a region of the alpha subunit called the CaM binding domain (CaMBD), located intracellular and immediately C-terminal to the inner helix gate, in either the presence or absence of Ca2+. SK gating occurs when Ca2+ binds the N lobe of CaM thereby transmitting the signal to the attached inner helix gate to open. Here we present crystal structures of apoCaM… CONTINUE READING