Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

@article{Millard1999CrystalSO,
  title={Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.},
  author={C. Millard and G. Kryger and A. Ordentlich and H. Greenblatt and M. Harel and M. Raves and Y. Segall and D. Barak and A. Shafferman and I. Silman and J. Sussman},
  journal={Biochemistry},
  year={1999},
  volume={38 22},
  pages={
          7032-9
        }
}
  • C. Millard, G. Kryger, +8 authors J. Sussman
  • Published 1999
  • Chemistry, Medicine
  • Biochemistry
  • Organophosphorus acid anhydride (OP) nerve agents are potent inhibitors which rapidly phosphonylate acetylcholinesterase (AChE) and then may undergo an internal dealkylation reaction (called "aging") to produce an OP-enzyme conjugate that cannot be reactivated. To understand the basis for irreversible inhibition, we solved the structures of aged conjugates obtained by reaction of Torpedo californica AChE (TcAChE) with diisopropylphosphorofluoridate (DFP), O-isopropylmethylphosponofluoridate… CONTINUE READING
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