Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.


Pentameric ligand-gated ion channels (pLGICs) constitute a widespread class of ion channels, present in archaea, bacteria, and eukaryotes. Upon binding of their agonists in the extracellular domain, the transmembrane pore opens, allowing ions to go through, via a gating mechanism that can be modulated by a number of drugs. Even though high-resolution… (More)
DOI: 10.1073/pnas.1717700115


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