Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

@article{Ihara2008CrystalSO,
  title={Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin},
  author={M. Ihara and T. Okajima and A. Yamashita and T. Oda and Koichi Hirata and H. Nishiwaki and T. Morimoto and M. Akamatsu and Y. Ashikawa and Shun'ichi Kuroda and Ryosuke Mega and S. Kuramitsu and D. Sattelle and K. Matsuda},
  journal={Invertebrate Neuroscience},
  year={2008},
  volume={8},
  pages={71 - 81}
}
  • M. Ihara, T. Okajima, +11 authors K. Matsuda
  • Published 2008
  • Biology, Medicine
  • Invertebrate Neuroscience
  • Neonicotinoid insecticides, which act on nicotinic acetylcholine receptors (nAChRs) in a variety of ways, have extremely low mammalian toxicity, yet the molecular basis of such actions is poorly understood. To elucidate the molecular basis for nAChR–neonicotinoid interactions, a surrogate protein, acetylcholine binding protein from Lymnaea stagnalis (Ls-AChBP) was crystallized in complex with neonicotinoid insecticides imidacloprid (IMI) or clothianidin (CTD). The crystal structures suggested… CONTINUE READING
    Diverse Actions and Target-Site Selectivity of Neonicotinoids: Structural Insights
    • 103
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 73 REFERENCES
    Neonicotinoid insecticide toxicology: mechanisms of selective action.
    • 1,002
    • Highly Influential
    • Open Access
    Mapping the elusive neonicotinoid binding site
    • 55
    • Open Access
    Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
    • 269
    • Highly Influential
    • Open Access
    Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant
    • 283
    Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors.
    • 646