Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.

@article{Tong1995CrystalSO,
  title={Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere.},
  author={Liang Tong and Susan Pav and S. Y. Mui and D Lamarre and Christiane Yoakim and Philippe Beaulieu and Paul C. Anderson},
  journal={Structure},
  year={1995},
  volume={3 1},
  pages={33-40}
}
BACKGROUND The HIV protease is essential for the life cycle of the virus and is an important target for the development of therapeutic treatments against AIDS. The structures of HIV protease in complex with different inhibitors have helped in understanding the interactions between inhibitors and the protease and in the design and optimization of HIV protease inhibitors. RESULTS We report here crystal structures at up to 1.7 A resolution of the homodimeric HIV-2 protease in complex with seven… CONTINUE READING

Similar Papers

Loading similar papers…