Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei

@inproceedings{Kubota2018CrystalSO,
  title={Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei
},
  author={Tomomi Kubota and Osamu Tani and Tomohiko Yamaguchi and Ichiji Namatame and Hitoshi Sakashita and Koji Furukawa and Kazuhiko Yamasaki},
  booktitle={FEBS open bio},
  year={2018}
}
Dihydroorotate dehydrogenase (DHODH) is a flavin-binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three-dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery for neglected tropical diseases, especially because these enzymes possess significantly different structural and functional properties from the membrane-associated human enzyme. The existing crystal structures of the flavin mononucleotide (FMN)-bound… CONTINUE READING

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