Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

@article{Yang2008CrystalSO,
  title={Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA},
  author={Cai-Guang Yang and Chengqi Yi and Erica M. Duguid and Christopher T. Sullivan and Xing Jian and Phoebe A Rice and Chuan He},
  journal={Nature},
  year={2008},
  volume={452},
  pages={961-965}
}
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions and can repair damaged bases in RNA. Here we show the first crystal structures of AlkB–dsDNA and ABH2–dsDNA complexes, stabilized by a chemical… CONTINUE READING
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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

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