Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity.

Abstract

Candida albicans and Candida glabrata cause fungal bloodstream infections that are associated with significant mortality. As part of an effort to develop potent and selective antifolates that target dihydrofolate reductase (DHFR) from Candida species, we report three ternary crystal structures of C. albicans DHFR (CaDHFR) bound to novel propargyl-linked… (More)
DOI: 10.1111/j.1747-0285.2011.01169.x

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@article{Paulsen2011CrystalSO, title={Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity.}, author={Janet L. Paulsen and Stephen D Bendel and Amy C. Anderson}, journal={Chemical biology & drug design}, year={2011}, volume={78 4}, pages={505-12} }