Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.

@article{Katona2002CrystalSR,
  title={Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.},
  author={Gergely Katona and Gunnar I. Berglund and Janos Hajdu and L{\'a}szl{\'o} Gr{\'a}f and L{\'a}szl{\'o} Szil{\'a}gyi},
  journal={Journal of molecular biology},
  year={2002},
  volume={315 5},
  pages={
          1209-18
        }
}
Severe neurodegradative brain diseases, like Alzheimer, are tightly linked with proteolytic activity in the human brain. Proteinases expressed in the brain, such as human trypsin IV, are likely to be involved in the pathomechanism of these diseases. The observation of amyloid formed in the brain of transgenic mice expressing human trypsin IV supports this hypothesis. Human trypsin IV is also resistant towards all studied naturally occurring polypeptide inhibitors. It has been postulated that… CONTINUE READING

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