Crystal structure of unphosphorylated STAT3 core fragment.

  title={Crystal structure of unphosphorylated STAT3 core fragment.},
  author={Zhiyong Ren and Xiang Mao and Claudia Mertens and R KrishnaRaj and Jie Qin and Pijus Kumar Mandal and Michael J. Romanowski and John S. McMurray and Xiaomin Chen},
  journal={Biochemical and biophysical research communications},
  volume={374 1},
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcriptional factors that play an important role in cytokine and growth factor signaling. Here we report a 3.05 A-resolution crystal structure of an unphosphorylated STAT3 core fragment. The overall monomeric structure is very similar to that of the phosphorylated STAT3 core fragment. However, the dimer interface observed in the unphosphorylated STAT1 core fragment structure is absent in the STAT3 structure… CONTINUE READING
Highly Cited
This paper has 44 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 24 citations


Publications referenced by this paper.
Showing 1-10 of 29 references


  • C. Mertens, M. Zhong, R. Krishnaraj, W. Zou
  • Chen, J.E. Darnell Jr., Dephosphorylation of…
  • 2006
Highly Influential
4 Excerpts


  • X. Mao, Z. Ren, +4 authors J. S. McMurray
  • Demeler, J.E. Darnell Jr., X. Chen, Structural…
  • 2005
Highly Influential
7 Excerpts

Crystal structure of a tyrosine phosphorylated STAT1 dimer bound to DNA

  • U. Vinkemeier X. Chen, Y. Zhao, D. Jeruzalmi, J. E. Darnell, J. Kuriyan
  • 2007


  • C. P. Lim, X. Cao
  • function, and regulation of STAT proteins, Mol…
  • 2006

Implications of an antiparallel dimeric structure of nonphosphorylated STAT 1 for the activation – inactivation cycle

  • M. A. Henriksen, K. Takeuchi, +6 authors J. E. Darnell
  • Proc . Natl . Acad . Sci . USA
  • 2005