Crystal structure of type II peptide deformylase from Staphylococcus aureus.

  title={Crystal structure of type II peptide deformylase from Staphylococcus aureus.},
  author={Eric T. Baldwin and Melissa S Harris and Anthony W. Yem and Cindy L Wolfe and Anne F Vosters and Kimberly A Curry and Robert W. Murray and Jeffrey H Bock and Vincent P. Marshall and Joyce I. Cialdella and Mahesh H Merchant and Gil H. Choi and Martin R. Deibel},
  journal={The Journal of biological chemistry},
  volume={277 34},
The first crystal structure of Class II peptide deformylase has been determined. The enzyme from Staphylococcus aureus has been overexpressed and purified in Escherichia coli and the structure determined by x-ray crystallography to 1.9 A resolution. The purified iron-enriched form of S. aureus peptide deformylase enzyme retained high activity over many months. In contrast, the iron-enriched form of the E. coli enzyme is very labile. Comparison of the two structures details many differences… CONTINUE READING

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