Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.


p62/SQSTM1/A170 is a multimodular protein that is found in ubiquitin-positive inclusions associated with neurodegenerative diseases. Recent findings indicate that p62 mediates the interaction between ubiquitinated proteins and autophagosomes, leading these proteins to be degraded via the autophagy-lysosomal pathway. This ubiquitin-mediated selective… (More)
DOI: 10.1074/jbc.M111.259630