Crystal structure of the type IV secretion system component CagX from Helicobacter pylori

  title={Crystal structure of the type IV secretion system component CagX from Helicobacter pylori
  author={Jin Zhang and Fei Fan and Yanhe Zhao and Lifang Sun and Yadan Liu and Ronan M. Keegan and Michail N. Isupov and Yunkun Wu},
  booktitle={Acta crystallographica. Section F, Structural biology communications},
Helicobacter pylori, a Gram-negative bacterial pathogen prevalent in the human population, is the causative agent of severe gastric diseases. An H. pylori type IV secretion (T4S) system encoded by the cytotoxin-associated gene pathogenicity island (cagPAI) is responsible for communication with host cells. As a component of the cagPAI T4S system core complex, CagX plays an important role in virulence-protein translocation into the host cells. In this work, the crystal structure of the C-terminal… CONTINUE READING


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