Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli.

@article{Gawarzewski2014CrystalSO,
  title={Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli.},
  author={I. Gawarzewski and F. Dimaio and E. Winterer and Britta Tschapek and S. Smits and J. Jose and L. Schmitt},
  journal={Journal of structural biology},
  year={2014},
  volume={187 1},
  pages={
          20-29
        }
}
  • I. Gawarzewski, F. Dimaio, +4 authors L. Schmitt
  • Published 2014
  • Biology, Medicine
  • Journal of structural biology
  • Several serious gastrointestinal diseases, which are widespread all over the world, are caused by enteropathogenic Escherichia coli. The monomeric autotransporter AIDA-I (adhesin involved in diffuse adherence) represents an important virulence factor of these strains and is involved in adhesion, biofilm formation, aggregation and invasion into host cells. Here, we present the crystal structure of the transport unit of AIDA-I at 3.0Å resolution, which forms a 12-stranded β-barrel harboring the… CONTINUE READING
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