Crystal structure of the talin integrin binding domain 2.

@article{Cheung2009CrystalSO,
  title={Crystal structure of the talin integrin binding domain 2.},
  author={Tsz Ying Sylvia Cheung and Michael J. Fairchild and Raz Zarivach and Guy Tanentzapf and Filip Van Petegem},
  journal={Journal of molecular biology},
  year={2009},
  volume={387 4},
  pages={787-93}
}
Integrins are transmembrane receptors that mediate cell adhesion to the extracellular matrix and play essential roles in tissue development and maintenance. The cytoplasmic segment of integrin associates with talin, a large intracellular protein that links integrin to the actin cytoskeleton. Binding of talin via an integrin binding segment (IBS1) results in… CONTINUE READING