Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.

  title={Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.},
  author={Haruo Ogawa and Takehiro Shinoda and Flemming Cornelius and Chikashi Toyoshima},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 33},
The sodium-potassium pump (Na(+),K(+)-ATPase) is responsible for establishing Na(+) and K(+) concentration gradients across the plasma membrane and therefore plays an essential role in, for instance, generating action potentials. Cardiac glycosides, prescribed for congestive heart failure for more than 2 centuries, are efficient inhibitors of this ATPase. Here we describe a crystal structure of Na(+),K(+)-ATPase with bound ouabain, a representative cardiac glycoside, at 2.8 A resolution in a… CONTINUE READING
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