Crystal structure of the sodium–potassium pump

  title={Crystal structure of the sodium–potassium pump},
  author={J. P. Morth and B. Pedersen and M. Toustrup-Jensen and T. S{\o}rensen and J. Petersen and J. Andersen and B. Vilsen and P. Nissen},
  • J. P. Morth, B. Pedersen, +5 authors P. Nissen
  • Published 2007
  • Chemistry, Medicine
  • Nature
  • The Na+,K+-ATPase generates electrochemical gradients for sodium and potassium that are vital to animal cells, exchanging three sodium ions for two potassium ions across the plasma membrane during each cycle of ATP hydrolysis. Here we present the X-ray crystal structure at 3.5 Å resolution of the pig renal Na+,K+-ATPase with two rubidium ions bound (as potassium congeners) in an occluded state in the transmembrane part of the α-subunit. Several of the residues forming the cavity for rubidium… CONTINUE READING
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