Crystal structure of the ribosome recycling factor bound to the ribosome

  title={Crystal structure of the ribosome recycling factor bound to the ribosome},
  author={Albert Weixlbaumer and Sabine Petry and Christine M Dunham and Maria Selmer and Ann C. Kelley and V Ramakrishnan},
  journal={Nature Structural &Molecular Biology},
In bacteria, disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF), which works in concert with elongation factor G. Here we describe the crystal structure of the Thermus thermophilus RRF bound to a 70S ribosomal complex containing a stop codon in the A site, a transfer RNA anticodon stem-loop in the P site and tRNAfMet in the E site. The work demonstrates that structures of translation factors bound to 70S… CONTINUE READING

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