Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states.

@article{Bent2004CrystalSO,
  title={Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states.},
  author={Colin J. Bent and Neil W. Isaacs and Tim J Mitchell and Alan Riboldi-Tunnicliffe},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 9},
  pages={2872-9}
}
A variety of bacterial cellular responses to environmental signals are mediated by two-component signal transduction systems comprising a membrane-associated histidine protein kinase and a cytoplasmic response regulator (RR), which interpret specific stimuli and produce a measured physiological response. In RR activation, transient phosphorylation of a highly conserved aspartic acid residue drives the conformation changes needed for full activation of the protein. Sequence homology reveals that… CONTINUE READING

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