Crystal structure of the rabies virus nucleoprotein-RNA complex.

  title={Crystal structure of the rabies virus nucleoprotein-RNA complex.},
  author={Aur{\'e}lie A. V. Albertini and Amy K. Wernimont and Tadeusz Muziol and Raimond B G Ravelli and Cedric R. Clapier and Guy Schoehn and Winfried Weissenhorn and Rob W H Ruigrok},
  volume={313 5785},
Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid… CONTINUE READING
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