Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III.

@article{Jeruzalmi2001CrystalSO,
  title={Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III.},
  author={David Jeruzalmi and Mike O'Donnell and John Kuriyan},
  journal={Cell},
  year={2001},
  volume={106 4},
  pages={429-41}
}
The gamma complex, an AAA+ ATPase, is the bacterial homolog of eukaryotic replication factor C (RFC) that loads the sliding clamp (beta, homologous to PCNA) onto DNA. The 2.7/3.0 A crystal structure of gamma complex reveals a pentameric arrangement of subunits, with stoichiometry delta':gamma(3):delta. The C-terminal domains of the subunits form a circular collar that supports an asymmetric arrangement of the N-terminal ATP binding domains of the gamma motor and the structurally related domains… CONTINUE READING
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