Crystal structure of the nucleosome core particle at 2.8 Å resolution

@article{Luger1997CrystalSO,
  title={Crystal structure of the nucleosome core particle at 2.8 {\AA} resolution},
  author={K. Luger and A. W. M{\"a}der and R. K. Richmond and D. F. Sargent and T. Richmond},
  journal={Nature},
  year={1997},
  volume={389},
  pages={251-260}
}
  • K. Luger, A. W. Mäder, +2 authors T. Richmond
  • Published 1997
  • Materials Science, Chemistry, Medicine
  • Nature
  • The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The… CONTINUE READING

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