Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

@article{Kovall2004CrystalSO,
  title={Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.},
  author={Rhett A. Kovall and Wayne A. Hendrickson},
  journal={The EMBO journal},
  year={2004},
  volume={23 17},
  pages={3441-51}
}
Notch signaling is a conserved pathway of communication between neighboring cells that results in cell fate specification, and CSL is the universal transcriptional effector of Notch signaling. The Notch intracellular domain translocates to the nucleus after proteolytic release upon Notch extracellular engagement, and there it displaces corepressors from DNA-bound CSL and recruits activators of Notch target genes. Here we report the 2.85 A crystal structure of CSL with a target DNA. CSL… CONTINUE READING
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