Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

Abstract

Non-haem Fe(ii)/α-ketoglutarate (αKG)-dependent enzymes harness the reducing power of αKG to catalyse oxidative reactions, usually the hydroxylation of unactivated carbons, and are involved in processes such as natural product biosynthesis, the mammalian hypoxic response, and DNA repair. These enzymes couple the decarboxylation of αKG with the formation of… (More)
DOI: 10.1038/nature04544

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