Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

@article{Gong2008CrystalSO,
  title={Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex},
  author={Yong Gong and Peng Cao and Hong Yu and Tao Jiang},
  journal={Nature},
  year={2008},
  volume={454},
  pages={789-793}
}
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptors (Trks). Whereas p75NTR binds to all NTs, the Trk subtypes are specific for each NT. The question of whether NTs stimulate p75NTR by inducing receptor homodimerization is still under debate. Here we report the 2.6-Å resolution… 

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p75NTR – live or let die