Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

@article{Gong2008CrystalSO,
  title={Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex},
  author={Yong Gong and Peng Cao and Hong-jun Yu and Tao Jiang},
  journal={Nature},
  year={2008},
  volume={454},
  pages={789-793}
}
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptors (Trks). Whereas p75NTR binds to all NTs, the Trk subtypes are specific for each NT. The question of whether NTs stimulate p75NTR by inducing receptor homodimerization is still under debate. Here we report the 2.6-Å resolution… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
47 Extracted Citations
34 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 47 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors

  • T Wehrman
  • Neuron 53,
  • 2007

model-building tools for molecular graphics

  • P. Emsley, Cowtan, K. Coot
  • Acta Crystallogr. D Biol. Crystallogr. 60, 2126…
  • 2004

The PyMOL Molecular Graphics System

  • W. L. Delano
  • DeLano Scientific,
  • 2002

Similar Papers

Loading similar papers…